Protective Mechanisms of Mitochondria and Heart Function in Diabetes

Por Aon, Miguel A., Tocchetti, Carlo G., Bhatt, Niraj, Paolocci, Nazareno, Cortassa, Sonia
Publicado no Antioxid Redox Signal (2015)

Glutathione oxidation unmasks proarrhythmic vulnerability of chronically hyperglycemic guinea pigs

Por Xie, Chaoqin, Biary, Nora, Tocchetti, Carlo G., Aon, Miguel A., Paolocci, Nazareno, Kauffman, Justin, Akar, Fadi G.
Publicado em 2013

Mitral peak early diastolic filling velocity to deceleration time ratio as a predictor of prognosis in patients with chronic heart failure and preserved or reduced ejection fractio...

Por Pirozzi, Flora, Paglia, Antonella, Sasso, Laura, Abete, Pasquale, Carlomagno, Angelo, Tocchetti, Carlo G, Bonaduce, Domenico, Petretta, Mario
Publicado no J Geriatr Cardiol (2015)

The Pharmacology of Nitroxyl (HNO) and Its Therapeutic Potential: Not Just the Janus Face of NO()

Por Paolocci, Nazareno, Jackson, Matthew I., Lopez, Brenda E., Tocchetti, Carlo G., Wink, David A., Hobbs, Adrian, Fukuto, Jon M.
Publicado em 2006

Novel Perspectives in Redox Biology and Pathophysiology of Failing Myocytes: Modulation of the Intramyocardial Redox Milieu for Therapeutic Interventions—A Review Article from the...

Por Arcaro, Alessia, Pirozzi, Flora, Angelini, Annalisa, Chimenti, Cristina, Crotti, Lia, Giordano, Carla, Mancardi, Daniele, Torella, Daniele, Tocchetti, Carlo G.
Publicado no Oxid Med Cell Longev (2016)

Nitroxyl enhances myocyte Ca(2+) transients by exclusively targeting SR Ca(2+)-cycling

Por Kohr, Mark J, Kaludercic, Nina, Tocchetti, Carlo G, Gao, Wei Dong, Kass, David A, Janssen, Paul ML, Paolocci, Nazareno, Ziolo, Mark T
Publicado em 2010

Recent Advances on Pathophysiology, Diagnostic and Therapeutic Insights in Cardiac Dysfunction Induced by Antineoplastic Drugs

Por Molinaro, Marilisa, Ameri, Pietro, Marone, Giancarlo, Petretta, Mario, Abete, Pasquale, Di Lisa, Fabio, De Placido, Sabino, Bonaduce, Domenico, Tocchetti, Carlo G.
Publicado no Biomed Res Int (2015)

Restoring redox balance enhances contractility in heart trabeculae from type 2 diabetic rats exposed to high glucose

Por Bhatt, Niraj M., Aon, Miguel A., Tocchetti, Carlo G., Shen, Xiaoxu, Dey, Swati, Ramirez-Correa, Genaro, O′Rourke, Brian, Gao, Wei Dong, Cortassa, Sonia
Publicado no Am J Physiol Heart Circ Physiol (2014)

A recommended practical approach to the management of target therapy and angiogenesis inhibitors cardiotoxicity: an opinion paper of the working group on drug cardiotoxicity and ca...

Por Maurea, Nicola, Spallarossa, Paolo, Cadeddu, Christian, Madonna, Rosalinda, Mele, Donato, Monte, Ines, Novo, Giuseppina, Pagliaro, Pasquale, Pepe, Alessia, Tocchetti, Carlo G., Zito, Concetta, Mercuro, Giuseppe
Publicado no J Cardiovasc Med (Hagerstown) (2016)

A recommended practical approach to the management of anthracycline-based chemotherapy cardiotoxicity: an opinion paper of the working group on drug cardiotoxicity and cardioprotec...

Por Spallarossa, Paolo, Maurea, Nicola, Cadeddu, Christian, Madonna, Rosalinda, Mele, Donato, Monte, Ines, Novo, Giuseppina, Pagliaro, Pasquale, Pepe, Alessia, Tocchetti, Carlo G., Zito, Concetta, Mercuro, Giuseppe
Publicado no J Cardiovasc Med (Hagerstown) (2016)

Playing with Cardiac “Redox Switches”: The “HNO Way” to Modulate Cardiac Function

Por Tocchetti, Carlo G., Stanley, Brian A., Murray, Christopher I., Sivakumaran, Vidhya, Donzelli, Sonia, Mancardi, Daniele, Pagliaro, Pasquale, Gao, Wei Dong, van Eyk, Jennifer, Kass, David A., Wink, David A., Paolocci, Nazareno
Publicado em 2011

GSH or Palmitate Preserves Mitochondrial Energetic/Redox Balance, Preventing Mechanical Dysfunction in Metabolically Challenged Myocytes/Hearts From Type 2 Diabetic Mice

Por Tocchetti, Carlo G., Caceres, Viviane, Stanley, Brian A., Xie, Chaoqin, Shi, Sa, Watson, Walter H., O’Rourke, Brian, Spadari-Bratfisch, Regina C., Cortassa, Sonia, Akar, Fadi G., Paolocci, Nazareno, Aon, Miguel A.
Publicado em 2012

CCR5 Inhibition Prevents Cardiac Dysfunction in the SIV/Macaque Model of HIV

Por Kelly, Kathleen M., Tocchetti, Carlo G., Lyashkov, Alexey, Tarwater, Patrick M., Bedja, Djahida, Graham, David R., Beck, Sarah E., Metcalf Pate, Kelly A., Queen, Suzanne E., Adams, Robert J., Paolocci, Nazareno, Mankowski, Joseph L.
Publicado em 2014

Constitutive BDNF/TrkB signaling is required for normal cardiac contraction and relaxation

Por Feng, Ning, Huke, Sabine, Zhu, Guangshuo, Tocchetti, Carlo G., Shi, Sa, Aiba, Takeshi, Kaludercic, Nina, Hoover, Donald B., Beck, Sarah E., Mankowski, Joseph L., Tomaselli, Gordon F., Bers, Donald M., Kass, David A., Paolocci, Nazareno
Publicado no Proc Natl Acad Sci U S A (2015)

Bidirectional cross-regulation between ErbB2 and β-adrenergic signalling pathways

Por Sysa-Shah, Polina, Tocchetti, Carlo G., Gupta, Manveen, Rainer, Peter P., Shen, Xiaoxu, Kang, Byung-Hak, Belmonte, Frances, Li, Jian, Xu, Yi, Guo, Xin, Bedja, Djahida, Gao, Wei Dong, Paolocci, Nazareno, Rath, Rutwik, Sawyer, Douglas B., Naga Prasad, Sathyamangla V., Gabrielson, Kathleen
Publicado no Cardiovasc Res (2016)

Reversal of Cardiac Hypertrophy and Fibrosis from Pressure-Overload by Tetrahydrobiopterin: Efficacy of re-coupling nitric oxide synthase as a therapeutic strategy

Por Moens, An L., Takimoto, Eiki, Tocchetti, Carlo G., Chakir, Khalid, Bedja, Djahida, Cormaci, Gianfranco, Ketner, Elizabeth A., Majmudar, Maulik, Gabrielson, Kathleen, Halushka, Marc K., Mitchell, James B., Biswal, Shyam, Channon, Keith M., Wolin, Mike S., Alp, Nicholas J., Paolocci, Nazareno, Champion, Hunter C., Kass, David A.
Publicado em 2008

Nitroxyl Improves Cellular Heart Function by Directly Enhancing Cardiac Sarcoplasmic Reticulum Ca2(+) Cycling

Por Tocchetti, Carlo G., Wang, Wang, Froehlich, Jeffrey P., Huke, Sabine, Aon, Miguel A., Wilson, Gerald M., Benedetto, Giulietta Di, O’Rourke, Brian, Gao, Wei Dong, Wink, David A., Toscano, John P., Zaccolo, Manuela, Bers, Donald M., Valdivia, Hector H., Cheng, Heping, Kass, David A., Paolocci, Nazareno
Publicado em 2006

HNO Enhances SERCA2a Activity and Cardiomyocyte Function by Promoting Redox-Dependent Phospholamban Oligomerization

Por Sivakumaran, Vidhya, Stanley, Brian A., Tocchetti, Carlo G., Ballin, Jeff D., Caceres, Viviane, Zhou, Lufang, Keceli, Gizem, Rainer, Peter P., Lee, Dong I., Huke, Sabine, Ziolo, Mark T., Kranias, Evangelia G., Toscano, John P., Wilson, Gerald M., O'Rourke, Brian, Kass, David A., Mahaney, James E., Paolocci, Nazareno
Publicado em 2013