Nitroxyl enhances myocyte Ca(2+) transients by exclusively targeting SR Ca(2+)-cycling

Nitroxyl (HNO), the 1-electron reduction product of nitric oxide, improves myocardial contraction in normal and failing hearts. Here we test whether the HNO donor Angeli’s salt (AS) will change myocyte action potential (AP) waveform by altering the L-type Ca(2+) current (ICa) and contrast the contra...

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Bibliographic Details
Main Authors: Kohr, Mark J, Kaludercic, Nina, Tocchetti, Carlo G, Gao, Wei Dong, Kass, David A, Janssen, Paul ML, Paolocci, Nazareno, Ziolo, Mark T
Format: Artigo
Language:Inglês
Published: 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057191/
https://ncbi.nlm.nih.gov/pubmed/20036906
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