Nitroxyl enhances myocyte Ca(2+) transients by exclusively targeting SR Ca(2+)-cycling

Nitroxyl (HNO), the 1-electron reduction product of nitric oxide, improves myocardial contraction in normal and failing hearts. Here we test whether the HNO donor Angeli’s salt (AS) will change myocyte action potential (AP) waveform by altering the L-type Ca(2+) current (ICa) and contrast the contra...

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Hauptverfasser: Kohr, Mark J, Kaludercic, Nina, Tocchetti, Carlo G, Gao, Wei Dong, Kass, David A, Janssen, Paul ML, Paolocci, Nazareno, Ziolo, Mark T
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057191/
https://ncbi.nlm.nih.gov/pubmed/20036906
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