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Induced overexpression of Na(+)/Ca(2+) exchanger transgene: altered myocyte contractility, [Ca(2+)](i) transients, SR Ca(2+) contents, and action potential duration
We have produced mice in which expression of the rat cardiac Na(+)/Ca(2+) exchanger (NCX1) transgene was switched on when doxycycline was removed from the feed at 5 wk. At 8 to 10 wk, NCX1 expression in induced (Ind) mouse hearts was 2.5-fold higher but protein levels of sarco(endo)plasmic reticulum...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Physiological Society
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2724197/ https://ncbi.nlm.nih.gov/pubmed/19525383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00190.2009 |
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