Regulation of in vivo cardiac contractility by phospholemman: role of Na(+)/Ca(2+) exchange

Phospholemman (PLM), when phosphorylated at serine 68, relieves its inhibition on Na(+)-K(+)-ATPase but inhibits Na(+)/Ca(2+) exchanger 1 (NCX1) in cardiac myocytes. Under stress when catecholamine levels are high, enhanced Na(+)-K(+)-ATPase activity by phosphorylated PLM attenuates intracellular Na...

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Détails bibliographiques
Auteurs principaux: Wang, JuFang, Gao, Erhe, Rabinowitz, Joseph, Song, Jianliang, Zhang, Xue-Qian, Koch, Walter J., Tucker, Amy L., Chan, Tung O., Feldman, Arthur M., Cheung, Joseph Y.
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2011
Sujets:
Muscle Mechanics and Ventricular Function
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064295/
https://ncbi.nlm.nih.gov/pubmed/21193587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00894.2010
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