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Regulation of in vivo cardiac contractility by phospholemman: role of Na(+)/Ca(2+) exchange
Phospholemman (PLM), when phosphorylated at serine 68, relieves its inhibition on Na(+)-K(+)-ATPase but inhibits Na(+)/Ca(2+) exchanger 1 (NCX1) in cardiac myocytes. Under stress when catecholamine levels are high, enhanced Na(+)-K(+)-ATPase activity by phosphorylated PLM attenuates intracellular Na...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Physiological Society
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3064295/ https://ncbi.nlm.nih.gov/pubmed/21193587 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00894.2010 |
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