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Regulation of cardiac myocyte contractility by phospholemman: Na(+)/Ca(2+) exchange versus Na(+)-K(+)-ATPase
Phospholemman (PLM) regulates cardiac Na(+)/Ca(2+) exchanger (NCX1) and Na(+)-K(+)-ATPase in cardiac myocytes. PLM, when phosphorylated at Ser(68), disinhibits Na(+)-K(+)-ATPase but inhibits NCX1. PLM regulates cardiac contractility by modulating Na(+)-K(+)-ATPase and/or NCX1. In this study, we firs...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Physiological Society
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2593504/ https://ncbi.nlm.nih.gov/pubmed/18708446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00287.2008 |
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