Regulation of cardiac myocyte contractility by phospholemman: Na(+)/Ca(2+) exchange versus Na(+)-K(+)-ATPase

Phospholemman (PLM) regulates cardiac Na(+)/Ca(2+) exchanger (NCX1) and Na(+)-K(+)-ATPase in cardiac myocytes. PLM, when phosphorylated at Ser(68), disinhibits Na(+)-K(+)-ATPase but inhibits NCX1. PLM regulates cardiac contractility by modulating Na(+)-K(+)-ATPase and/or NCX1. In this study, we firs...

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Detalhes bibliográficos
Main Authors: Song, Jianliang, Zhang, Xue-Qian, Wang, JuFang, Cheskis, Ellina, Chan, Tung O., Feldman, Arthur M., Tucker, Amy L., Cheung, Joseph Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593504/
https://ncbi.nlm.nih.gov/pubmed/18708446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00287.2008
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