Phospholemman inhibition of the cardiac Na(+)/Ca(2+) exchanger: Role of phosphorylation.

We have previously demonstrated that phospholemman (PLM), a 15 kDa integral sarcolemmal phosphoprotein, inhibits the cardiac Na(+)/Ca(2+) exchanger (NCX1). In addition, p rotein kinase A phosphorylates serine(68) while protein kinase C phosphorylates both serine(63) and serine(68) of PLM. Using HEK2...

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Main Authors: Zhang, Xue-Qian, Ahlers, Belinda A., Tucker, Amy L., Song, Jianliang, Wang, JuFang, Moorman, J. Randall, Mounsey, J. Paul, Carl, Lois L., Rothblum, Lawrence I., Cheung, Joseph Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1405234/
https://ncbi.nlm.nih.gov/pubmed/16434394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M512092200
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