HNO Enhances SERCA2a Activity and Cardiomyocyte Function by Promoting Redox-Dependent Phospholamban Oligomerization

Aims: Nitroxyl (HNO) interacts with thiols to act as a redox-sensitive modulator of protein function. It enhances sarcoplasmic reticular Ca(2+) uptake and myofilament Ca(2+) sensitivity, improving cardiac contractility. This activity has led to clinical testing of HNO donors for heart failure. Here...

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Main Authors: Sivakumaran, Vidhya, Stanley, Brian A., Tocchetti, Carlo G., Ballin, Jeff D., Caceres, Viviane, Zhou, Lufang, Keceli, Gizem, Rainer, Peter P., Lee, Dong I., Huke, Sabine, Ziolo, Mark T., Kranias, Evangelia G., Toscano, John P., Wilson, Gerald M., O'Rourke, Brian, Kass, David A., Mahaney, James E., Paolocci, Nazareno
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2013
Fag:
Forum Original Research CommunicationsNitric Oxide Effects (P. Eaton and J. Burgoyne, Eds.)
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785857/
https://ncbi.nlm.nih.gov/pubmed/23919584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2012.5057
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