HNO Enhances SERCA2a Activity and Cardiomyocyte Function by Promoting Redox-Dependent Phospholamban Oligomerization

Aims: Nitroxyl (HNO) interacts with thiols to act as a redox-sensitive modulator of protein function. It enhances sarcoplasmic reticular Ca(2+) uptake and myofilament Ca(2+) sensitivity, improving cardiac contractility. This activity has led to clinical testing of HNO donors for heart failure. Here...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Sivakumaran, Vidhya, Stanley, Brian A., Tocchetti, Carlo G., Ballin, Jeff D., Caceres, Viviane, Zhou, Lufang, Keceli, Gizem, Rainer, Peter P., Lee, Dong I., Huke, Sabine, Ziolo, Mark T., Kranias, Evangelia G., Toscano, John P., Wilson, Gerald M., O'Rourke, Brian, Kass, David A., Mahaney, James E., Paolocci, Nazareno
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Mary Ann Liebert, Inc. 2013
Gaiak:
Forum Original Research CommunicationsNitric Oxide Effects (P. Eaton and J. Burgoyne, Eds.)
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785857/
https://ncbi.nlm.nih.gov/pubmed/23919584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2012.5057
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