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SERCA2a superinhibition by human phospholamban triggers electrical and structural remodeling in mouse hearts
Phospholamban (PLN), the reversible inhibitor of the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA2a), is a key regulator of myocyte Ca(2+) cycling with a significant role in heart failure. We previously showed that the single amino acid difference between human and mouse PLN results in increase...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3092331/ https://ncbi.nlm.nih.gov/pubmed/21266500 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00032.2010 |
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