Nitroxyl (HNO) targets phospholamban cysteines 41 and 46 to enhance cardiac function

Nitroxyl (HNO) positively modulates myocardial function by accelerating Ca(2+) reuptake into the sarcoplasmic reticulum (SR). HNO-induced enhancement of myocardial Ca(2+) cycling and function is due to the modification of cysteines in the transmembrane domain of phospholamban (PLN), which results in...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:J Gen Physiol
Main Authors: Keceli, Gizem, Majumdar, Ananya, Thorpe, Chevon N., Jun, Seungho, Tocchetti, Carlo G., Lee, Dong I., Mahaney, James E., Paolocci, Nazareno, Toscano, John P.
Formato: Artigo
Idioma:Inglês
Publicado: Rockefeller University Press 2019
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6571998/
https://ncbi.nlm.nih.gov/pubmed/30842219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201812208
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares