Nitroxyl (HNO) a Novel Approach for the Acute Treatment of Heart Failure

BACKGROUND: The nitroxyl (HNO) donor, Angeli’s salt (AS), exerts positive inotropic, lusitropic, and vasodilator effects in vivo that are cyclic AMP-independent. Its clinical utility is limited by chemical instability and co-generation of nitrite that itself has vascular effects. Here we report on e...

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Detalhes bibliográficos
Main Authors: Sabbah, Hani N., Tocchetti, Carlo Gabriele, Wang, Mengjun, Daya, Samantapudi, Gupta, Ramesh C., Tunin, Richard S., Mazhari, Reza, Takimoto, Eiki, Paolocci, Nazareno, Cowart, Douglas, Colucci, Wilson S., Kass, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110196/
https://ncbi.nlm.nih.gov/pubmed/24107588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.113.000632
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