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Nitroxyl (HNO) targets phospholamban cysteines 41 and 46 to enhance cardiac function
Nitroxyl (HNO) positively modulates myocardial function by accelerating Ca(2+) reuptake into the sarcoplasmic reticulum (SR). HNO-induced enhancement of myocardial Ca(2+) cycling and function is due to the modification of cysteines in the transmembrane domain of phospholamban (PLN), which results in...
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| Publicado no: | J Gen Physiol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6571998/ https://ncbi.nlm.nih.gov/pubmed/30842219 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201812208 |
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