Constitutive BDNF/TrkB signaling is required for normal cardiac contraction and relaxation

BDNF and its associated tropomyosin-related kinase receptor B (TrkB) nurture vessels and nerves serving the heart. However, the direct effect of BDNF/TrkB signaling on the myocardium is poorly understood. Here we report that cardiac-specific TrkB knockout mice (TrkB(−/−)) display impaired cardiac co...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Feng, Ning, Huke, Sabine, Zhu, Guangshuo, Tocchetti, Carlo G., Shi, Sa, Aiba, Takeshi, Kaludercic, Nina, Hoover, Donald B., Beck, Sarah E., Mankowski, Joseph L., Tomaselli, Gordon F., Bers, Donald M., Kass, David A., Paolocci, Nazareno
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330748/
https://ncbi.nlm.nih.gov/pubmed/25583515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417949112
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