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Synthesis of bis-Phosphate Iminoaltritol Enantiomers and Structural Characterization with Adenine Phosphoribosyltransferase

Phosphoribosyl transferases (PRTs) are essential in nucleotide synthesis and salvage, amino acid, and vitamin synthesis. Transition state analysis of several PRTs has demonstrated ribocation-like transition states with a partial positive charge residing on the pentose ring. Core chemistry for synthe...

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Bibliografski detalji
Izdano u:ACS Chem Biol
Glavni autori: Harris, Lawrence D., Harijan, Rajesh K., Ducati, Rodrigo G., Evans, Gary B., Hirsch, Brett M., Schramm, Vern L.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6568317/
https://ncbi.nlm.nih.gov/pubmed/29178779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00601
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