Synthesis of bis-Phosphate Iminoaltritol Enantiomers and Structural Characterization with Adenine Phosphoribosyltransferase

Phosphoribosyl transferases (PRTs) are essential in nucleotide synthesis and salvage, amino acid, and vitamin synthesis. Transition state analysis of several PRTs has demonstrated ribocation-like transition states with a partial positive charge residing on the pentose ring. Core chemistry for synthe...

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Библиографические подробности
Опубликовано в: :ACS Chem Biol
Главные авторы: Harris, Lawrence D., Harijan, Rajesh K., Ducati, Rodrigo G., Evans, Gary B., Hirsch, Brett M., Schramm, Vern L.
Формат: Artigo
Язык:Inglês
Опубликовано: 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6568317/
https://ncbi.nlm.nih.gov/pubmed/29178779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00601
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