Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase

Bacterial 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN) hydrolyzes adenine from its substrates to form S-methyl-5-thioribose and S-ribosyl-l-homocysteine. MTANs are involved in quorum sensing, menaquinone synthesis, and 5′-methylthioadenosine recycling to S-adenosylmethionine. He...

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Publié dans:J Med Chem
Auteurs principaux: Harijan, Rajesh K., Hoff, Oskar, Ducati, Rodrigo G., Firestone, Ross S., Hirsch, Brett M., Evans, Gary B., Schramm, Vern L., Tyler, Peter C.
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6635953/
https://ncbi.nlm.nih.gov/pubmed/30860833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01642
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