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AAA: triple adaptive Bayesian designs for the identification of optimal dose combinations in dual-agent dose finding trials
We propose a flexible design for the identification of optimal dose combinations in dual-agent dose finding clinical trials. The design is called AAA, standing for three adaptations: adaptive model selection, adaptive dose insertion and adaptive cohort division. The adaptations highlight the need an...
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| 出版年: | J R Stat Soc Ser C Appl Stat |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6561465/ https://ncbi.nlm.nih.gov/pubmed/31190687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/rssc.12291 |
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