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AAA: triple adaptive Bayesian designs for the identification of optimal dose combinations in dual-agent dose finding trials
We propose a flexible design for the identification of optimal dose combinations in dual-agent dose finding clinical trials. The design is called AAA, standing for three adaptations: adaptive model selection, adaptive dose insertion and adaptive cohort division. The adaptations highlight the need an...
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| Publicado no: | J R Stat Soc Ser C Appl Stat |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6561465/ https://ncbi.nlm.nih.gov/pubmed/31190687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/rssc.12291 |
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