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Adaptive Designs for Identifying Optimal Biological Dose for Molecularly Targeted Agents

BACKGROUND: Traditionally, the purpose of a dose-finding design in cancer is to find the maximum tolerated dose based solely on toxicity. However, for molecularly targeted agents, little toxicity may arise within the therapeutic dose range and the dose-response curves may not be monotonic. This chal...

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Detalhes bibliográficos
Publicado no:Clin Trials
Main Authors: Zang, Yong, Lee, J Jack, Yuan, Ying
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239216/
https://ncbi.nlm.nih.gov/pubmed/24844841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774514529848
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