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Adaptive Designs for Identifying Optimal Biological Dose for Molecularly Targeted Agents
BACKGROUND: Traditionally, the purpose of a dose-finding design in cancer is to find the maximum tolerated dose based solely on toxicity. However, for molecularly targeted agents, little toxicity may arise within the therapeutic dose range and the dose-response curves may not be monotonic. This chal...
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| Publié dans: | Clin Trials |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4239216/ https://ncbi.nlm.nih.gov/pubmed/24844841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774514529848 |
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