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A Bayesian Dose-finding Design for Oncology Clinical Trials of Combinational Biological Agents
Treating patients with novel biological agents is becoming a leading trend in oncology. Unlike cytotoxic agents, for which efficacy and toxicity monotonically increase with dose, biological agents may exhibit non-monotonic patterns in their dose-response relationships. Using a trial with two biologi...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3913186/ https://ncbi.nlm.nih.gov/pubmed/24511160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/rssc.12039 |
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