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Bayesian hybrid dose-finding design in phase I oncology clinical trials

In oncology, dose escalation is often carried out to search for the maximum tolerated dose (MTD) in phase I clinical trials. We propose a Bayesian hybrid dose-finding method that inherits the robustness of model-free methods and the efficiency of model-based methods. In the Bayesian hypothesis testi...

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Bibliografiske detaljer
Main Authors: Yuan, Ying, Yin, Guosheng
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286188/
https://ncbi.nlm.nih.gov/pubmed/21365672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.4164
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