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A dose–schedule finding design for phase I–II clinical trials

Dose-finding methods aiming at identifying an optimal dose of a treatment with a given schedule may be at a risk of misidentifying the best treatment for patients. In this article we propose a phase I/II clinical trial design to find the optimal dose-schedule combination. We define schedule as the m...

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Bibliografiske detaljer
Udgivet i:J R Stat Soc Ser C Appl Stat
Main Authors: Guo, Beibei, Li, Yisheng, Yuan, Ying
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747255/
https://ncbi.nlm.nih.gov/pubmed/26877554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/rssc.12113
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