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Bayesian hybrid dose-finding design in phase I oncology clinical trials
In oncology, dose escalation is often carried out to search for the maximum tolerated dose (MTD) in phase I clinical trials. We propose a Bayesian hybrid dose-finding method that inherits the robustness of model-free methods and the efficiency of model-based methods. In the Bayesian hypothesis testi...
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| Glavni autori: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3286188/ https://ncbi.nlm.nih.gov/pubmed/21365672 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.4164 |
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