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Bayesian dose-finding designs for combination of molecularly targeted agents assuming partial stochastic ordering

Molecularly targeted agent (MTA) combination therapy is in the early stages of development. When using a fixed dose of one agent in combinations of MTAs, toxicity and efficacy do not necessarily increase with an increasing dose of the other agent. Thus, in dose-finding trials for combinations of MTA...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Stat Med
Asıl Yazarlar: Guo, Beibei, Li, Yisheng
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BlackWell Publishing Ltd 2014
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359011/
https://ncbi.nlm.nih.gov/pubmed/25413162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.6376
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