Wiskott–Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma

In T lymphocytes WASP and WIP regulate TCR signaling but their role in lymphoma is largely unknown. Here we show that the expression of WASP and WIP is frequently low or absent in anaplastic large cell lymphoma (ALCL) compared to other T cell lymphomas. In ALK+ ALCL, WASP and WIP expression is regul...

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Veröffentlicht in:Nat Med
Hauptverfasser: Menotti, Matteo, Ambrogio, Chiara, Cheong, Taek-Chin, Pighi, Chiara, Mota, Ines, Cassel, Seth H., Compagno, Mara, Wang, Qi, Dall’Olio, Riccardo, Minero, Valerio, Poggio, Teresa, Sharma, Geeta Geeta, Patrucco, Enrico, Mastini, Cristina, Choudhari, Ramesh, Pich, Achille, Zamo’, Alberto, Piva, Roberto, Giliani, Silvia, Mologni, Luca, Collings, Clayton K., Kadoch, Cigall, Gambacorti-Passerini, Carlo, Notarangelo, Luigi D., Anton, Ines M., Voena, Claudia, Chiarle, Roberto
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6556382/
https://ncbi.nlm.nih.gov/pubmed/30510251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0262-9
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