Wiskott–Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma

In T lymphocytes WASP and WIP regulate TCR signaling but their role in lymphoma is largely unknown. Here we show that the expression of WASP and WIP is frequently low or absent in anaplastic large cell lymphoma (ALCL) compared to other T cell lymphomas. In ALK+ ALCL, WASP and WIP expression is regul...

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Publicado en:Nat Med
Autores principales: Menotti, Matteo, Ambrogio, Chiara, Cheong, Taek-Chin, Pighi, Chiara, Mota, Ines, Cassel, Seth H., Compagno, Mara, Wang, Qi, Dall’Olio, Riccardo, Minero, Valerio, Poggio, Teresa, Sharma, Geeta Geeta, Patrucco, Enrico, Mastini, Cristina, Choudhari, Ramesh, Pich, Achille, Zamo’, Alberto, Piva, Roberto, Giliani, Silvia, Mologni, Luca, Collings, Clayton K., Kadoch, Cigall, Gambacorti-Passerini, Carlo, Notarangelo, Luigi D., Anton, Ines M., Voena, Claudia, Chiarle, Roberto
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6556382/
https://ncbi.nlm.nih.gov/pubmed/30510251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0262-9
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