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Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency
Most of Anaplastic Large Cell Lymphoma (ALCL) cases carry the t(2;5; p23;q35) that produces the fusion protein NPM-ALK. NPM-ALK deregulated kinase activity drives several pathways that support malignant transformation of lymphoma cells. We found that in ALK-rearranged ALCL cell lines NPM-ALK was dis...
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| Publicado no: | Oncogene |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4907875/ https://ncbi.nlm.nih.gov/pubmed/26657151 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.456 |
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