Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency

Most of Anaplastic Large Cell Lymphoma (ALCL) cases carry the t(2;5; p23;q35) that produces the fusion protein NPM-ALK. NPM-ALK deregulated kinase activity drives several pathways that support malignant transformation of lymphoma cells. We found that in ALK-rearranged ALCL cell lines NPM-ALK was dis...

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Udgivet i:Oncogene
Main Authors: Ceccon, Monica, Merlo, Maria Elena Boggio, Mologni, Luca, Poggio, Teresa, Varesio, Lydia M., Menotti, Matteo, Bombelli, Silvia, Rigolio, Roberta, Manazza, Andrea D., Di Giacomo, Filomena, Ambrogio, Chiara, Giudici, Giovanni, Casati, Cesare, Mastini, Cristina, Compagno, Mara, Turner, Suzanne D., Gambacorti-Passerini, Carlo, Chiarle, Roberto, Voena, Claudia
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907875/
https://ncbi.nlm.nih.gov/pubmed/26657151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.456
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