Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency

Most of Anaplastic Large Cell Lymphoma (ALCL) cases carry the t(2;5; p23;q35) that produces the fusion protein NPM-ALK. NPM-ALK deregulated kinase activity drives several pathways that support malignant transformation of lymphoma cells. We found that in ALK-rearranged ALCL cell lines NPM-ALK was dis...

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Publicado en:Oncogene
Autores principales: Ceccon, Monica, Merlo, Maria Elena Boggio, Mologni, Luca, Poggio, Teresa, Varesio, Lydia M., Menotti, Matteo, Bombelli, Silvia, Rigolio, Roberta, Manazza, Andrea D., Di Giacomo, Filomena, Ambrogio, Chiara, Giudici, Giovanni, Casati, Cesare, Mastini, Cristina, Compagno, Mara, Turner, Suzanne D., Gambacorti-Passerini, Carlo, Chiarle, Roberto, Voena, Claudia
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907875/
https://ncbi.nlm.nih.gov/pubmed/26657151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.456
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