The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells

Reactivation of fetal hemoglobin (HbF) production benefits patients with sickle cell disease and β-thalassemia. To identify new HbF regulators that might be amenable to pharmacologic control, we screened a protein domain–focused CRISPR-Cas9 library targeting chromatin regulators, including BTB domai...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Lan, Xianjiang, Khandros, Eugene, Huang, Peng, Peslak, Scott A., Bhardwaj, Saurabh K., Grevet, Jeremy D., Abdulmalik, Osheiza, Wang, Hongxin, Keller, Cheryl A., Giardine, Belinda, Baeza, Josue, Duffner, Emily R., El Demerdash, Osama, Wu, Xiaoli S., Vakoc, Christopher R., Garcia, Benjamin A., Hardison, Ross C., Shi, Junwei, Blobel, Gerd A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538866/
https://ncbi.nlm.nih.gov/pubmed/31126914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019032318
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados