Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells

Increasing fetal hemoglobin (HbF) levels in adult red blood cells provides clinical benefit to patients with sickle cell disease and some forms of β-thalassemia.To identify potentially druggable HbF regulators in adult human erythroid cells, we employed a protein kinase domain–focused CRISPR-Cas9–ba...

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Xehetasun bibliografikoak
Argitaratua izan da:Science
Egile Nagusiak: Grevet, Jeremy D., Lan, Xianjiang, Hamagami, Nicole, Edwards, Christopher R., Sankaranarayanan, Laavanya, Ji, Xinjun, Bhardwaj, Saurabh K., Face, Carolyne J., Posocco, David F., Abdulmalik, Osheiza, Keller, Cheryl A., Giardine, Belinda, Sidoli, Simone, Garcia, Ben A., Chou, Stella T., Liebhaber, Stephen A., Hardison, Ross C., Shi, Junwei, Blobel, Gerd A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6257981/
https://ncbi.nlm.nih.gov/pubmed/30026227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aao0932
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