Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells

Increasing fetal hemoglobin (HbF) levels in adult red blood cells provides clinical benefit to patients with sickle cell disease and some forms of β-thalassemia.To identify potentially druggable HbF regulators in adult human erythroid cells, we employed a protein kinase domain–focused CRISPR-Cas9–ba...

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Publicado no:Science
Main Authors: Grevet, Jeremy D., Lan, Xianjiang, Hamagami, Nicole, Edwards, Christopher R., Sankaranarayanan, Laavanya, Ji, Xinjun, Bhardwaj, Saurabh K., Face, Carolyne J., Posocco, David F., Abdulmalik, Osheiza, Keller, Cheryl A., Giardine, Belinda, Sidoli, Simone, Garcia, Ben A., Chou, Stella T., Liebhaber, Stephen A., Hardison, Ross C., Shi, Junwei, Blobel, Gerd A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6257981/
https://ncbi.nlm.nih.gov/pubmed/30026227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aao0932
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