The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression

Reactivation of fetal hemoglobin remains a critical goal in the treatment of patients with sickle cell disease and β-thalassemia. Previously, we discovered that silencing of the fetal γ-globin gene requires the erythroid-specific eIF2α kinase heme-regulated inhibitor (HRI), suggesting that HRI might...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Blood
Main Authors: Huang, Peng, Peslak, Scott A., Lan, Xianjiang, Khandros, Eugene, Yano, Jennifer A., Sharma, Malini, Keller, Cheryl A., Giardine, Belinda, Qin, Kunhua, Abdulmalik, Osheiza, Hardison, Ross C., Shi, Junwei, Blobel, Gerd A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Plenary Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7290097/
https://ncbi.nlm.nih.gov/pubmed/32299090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020005301
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados