The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression

Reactivation of fetal hemoglobin remains a critical goal in the treatment of patients with sickle cell disease and β-thalassemia. Previously, we discovered that silencing of the fetal γ-globin gene requires the erythroid-specific eIF2α kinase heme-regulated inhibitor (HRI), suggesting that HRI might...

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Bibliografiske detaljer
Udgivet i:Blood
Main Authors: Huang, Peng, Peslak, Scott A., Lan, Xianjiang, Khandros, Eugene, Yano, Jennifer A., Sharma, Malini, Keller, Cheryl A., Giardine, Belinda, Qin, Kunhua, Abdulmalik, Osheiza, Hardison, Ross C., Shi, Junwei, Blobel, Gerd A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2020
Fag:
Plenary Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7290097/
https://ncbi.nlm.nih.gov/pubmed/32299090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020005301
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