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The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression
Reactivation of fetal hemoglobin remains a critical goal in the treatment of patients with sickle cell disease and β-thalassemia. Previously, we discovered that silencing of the fetal γ-globin gene requires the erythroid-specific eIF2α kinase heme-regulated inhibitor (HRI), suggesting that HRI might...
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| Vydáno v: | Blood |
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| Hlavní autoři: | , , , , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society of Hematology
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7290097/ https://ncbi.nlm.nih.gov/pubmed/32299090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020005301 |
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