Understanding heterogeneity of fetal hemoglobin induction through comparative analysis of F and A erythroblasts

Reversing the developmental switch from fetal hemoglobin (HbF, α(2)γ(2)) to adult hemoglobin (HbA, α(2)β(2)) is an important therapeutic approach in sickle cell disease (SCD) and β-thalassemia. In healthy individuals, SCD patients, and patients treated with pharmacologic HbF inducers, HbF is present...

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Vydáno v:Blood
Hlavní autoři: Khandros, Eugene, Huang, Peng, Peslak, Scott A., Sharma, Malini, Abdulmalik, Osheiza, Giardine, Belinda M., Zhang, Zhe, Keller, Cheryl A., Hardison, Ross C., Blobel, Gerd A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2020
Témata:
Red Cells, Iron, and Erythropoiesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7256358/
https://ncbi.nlm.nih.gov/pubmed/32268371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020005058
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