Forced chromatin looping raises fetal hemoglobin in adult sickle cells to higher levels than pharmacologic inducers

Overcoming the silencing of the fetal γ-globin gene has been a long-standing goal in the treatment of sickle cell disease (SCD). The major transcriptional enhancer of the β-globin locus, called the locus control region (LCR), dynamically interacts with the developmental stage-appropriate β-type glob...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Blood
Main Authors: Breda, Laura, Motta, Irene, Lourenco, Silvia, Gemmo, Chiara, Deng, Wulan, Rupon, Jeremy W., Abdulmalik, Osheiza Y., Manwani, Deepa, Blobel, Gerd A., Rivella, Stefano
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5000846/
https://ncbi.nlm.nih.gov/pubmed/27405777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-01-691089
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados