Forced chromatin looping raises fetal hemoglobin in adult sickle cells to higher levels than pharmacologic inducers

Overcoming the silencing of the fetal γ-globin gene has been a long-standing goal in the treatment of sickle cell disease (SCD). The major transcriptional enhancer of the β-globin locus, called the locus control region (LCR), dynamically interacts with the developmental stage-appropriate β-type glob...

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Udgivet i:Blood
Main Authors: Breda, Laura, Motta, Irene, Lourenco, Silvia, Gemmo, Chiara, Deng, Wulan, Rupon, Jeremy W., Abdulmalik, Osheiza Y., Manwani, Deepa, Blobel, Gerd A., Rivella, Stefano
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2016
Fag:
Red Cells, Iron, and Erythropoiesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5000846/
https://ncbi.nlm.nih.gov/pubmed/27405777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-01-691089
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