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Reactivation of developmentally silenced globin genes by forced chromatin looping
Distal enhancers commonly contact target promoters via chromatin looping. In erythroid cells, the locus control region (LCR) contacts β-type globin genes in a developmental stage-specific manner to stimulate transcription. Previously, we induced LCR-promoter looping by tethering the self-association...
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Main Authors: | , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4134511/ https://ncbi.nlm.nih.gov/pubmed/25126789 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.05.050 |
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