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The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells
Reactivation of fetal hemoglobin (HbF) production benefits patients with sickle cell disease and β-thalassemia. To identify new HbF regulators that might be amenable to pharmacologic control, we screened a protein domain–focused CRISPR-Cas9 library targeting chromatin regulators, including BTB domai...
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| Pubblicato in: | Blood Adv |
|---|---|
| Autori principali: | , , , , , , , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society of Hematology
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6538866/ https://ncbi.nlm.nih.gov/pubmed/31126914 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019032318 |
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