The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells

Reactivation of fetal hemoglobin (HbF) production benefits patients with sickle cell disease and β-thalassemia. To identify new HbF regulators that might be amenable to pharmacologic control, we screened a protein domain–focused CRISPR-Cas9 library targeting chromatin regulators, including BTB domai...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Blood Adv
Egile Nagusiak: Lan, Xianjiang, Khandros, Eugene, Huang, Peng, Peslak, Scott A., Bhardwaj, Saurabh K., Grevet, Jeremy D., Abdulmalik, Osheiza, Wang, Hongxin, Keller, Cheryl A., Giardine, Belinda, Baeza, Josue, Duffner, Emily R., El Demerdash, Osama, Wu, Xiaoli S., Vakoc, Christopher R., Garcia, Benjamin A., Hardison, Ross C., Shi, Junwei, Blobel, Gerd A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2019
Gaiak:
Red Cells, Iron, and Erythropoiesis
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538866/
https://ncbi.nlm.nih.gov/pubmed/31126914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019032318
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak