The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells

Reactivation of fetal hemoglobin (HbF) production benefits patients with sickle cell disease and β-thalassemia. To identify new HbF regulators that might be amenable to pharmacologic control, we screened a protein domain–focused CRISPR-Cas9 library targeting chromatin regulators, including BTB domai...

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Foilsithe in:Blood Adv
Main Authors: Lan, Xianjiang, Khandros, Eugene, Huang, Peng, Peslak, Scott A., Bhardwaj, Saurabh K., Grevet, Jeremy D., Abdulmalik, Osheiza, Wang, Hongxin, Keller, Cheryl A., Giardine, Belinda, Baeza, Josue, Duffner, Emily R., El Demerdash, Osama, Wu, Xiaoli S., Vakoc, Christopher R., Garcia, Benjamin A., Hardison, Ross C., Shi, Junwei, Blobel, Gerd A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Hematology 2019
Ábhair:
Red Cells, Iron, and Erythropoiesis
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538866/
https://ncbi.nlm.nih.gov/pubmed/31126914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019032318
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