The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells

Reactivation of fetal hemoglobin (HbF) production benefits patients with sickle cell disease and β-thalassemia. To identify new HbF regulators that might be amenable to pharmacologic control, we screened a protein domain–focused CRISPR-Cas9 library targeting chromatin regulators, including BTB domai...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Blood Adv
Autors principals: Lan, Xianjiang, Khandros, Eugene, Huang, Peng, Peslak, Scott A., Bhardwaj, Saurabh K., Grevet, Jeremy D., Abdulmalik, Osheiza, Wang, Hongxin, Keller, Cheryl A., Giardine, Belinda, Baeza, Josue, Duffner, Emily R., El Demerdash, Osama, Wu, Xiaoli S., Vakoc, Christopher R., Garcia, Benjamin A., Hardison, Ross C., Shi, Junwei, Blobel, Gerd A.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2019
Matèries:
Red Cells, Iron, and Erythropoiesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538866/
https://ncbi.nlm.nih.gov/pubmed/31126914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019032318
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars