The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells

Reactivation of fetal hemoglobin (HbF) production benefits patients with sickle cell disease and β-thalassemia. To identify new HbF regulators that might be amenable to pharmacologic control, we screened a protein domain–focused CRISPR-Cas9 library targeting chromatin regulators, including BTB domai...

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Bibliografski detalji
Izdano u:Blood Adv
Glavni autori: Lan, Xianjiang, Khandros, Eugene, Huang, Peng, Peslak, Scott A., Bhardwaj, Saurabh K., Grevet, Jeremy D., Abdulmalik, Osheiza, Wang, Hongxin, Keller, Cheryl A., Giardine, Belinda, Baeza, Josue, Duffner, Emily R., El Demerdash, Osama, Wu, Xiaoli S., Vakoc, Christopher R., Garcia, Benjamin A., Hardison, Ross C., Shi, Junwei, Blobel, Gerd A.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2019
Teme:
Red Cells, Iron, and Erythropoiesis
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538866/
https://ncbi.nlm.nih.gov/pubmed/31126914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019032318
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