Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells

Increasing fetal hemoglobin (HbF) levels in adult red blood cells provides clinical benefit to patients with sickle cell disease and some forms of β-thalassemia.To identify potentially druggable HbF regulators in adult human erythroid cells, we employed a protein kinase domain–focused CRISPR-Cas9–ba...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Science
Main Authors: Grevet, Jeremy D., Lan, Xianjiang, Hamagami, Nicole, Edwards, Christopher R., Sankaranarayanan, Laavanya, Ji, Xinjun, Bhardwaj, Saurabh K., Face, Carolyne J., Posocco, David F., Abdulmalik, Osheiza, Keller, Cheryl A., Giardine, Belinda, Sidoli, Simone, Garcia, Ben A., Chou, Stella T., Liebhaber, Stephen A., Hardison, Ross C., Shi, Junwei, Blobel, Gerd A.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6257981/
https://ncbi.nlm.nih.gov/pubmed/30026227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aao0932
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares