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Exploiting genetic variation to uncover rules of transcription factor binding and chromatin accessibility

Single-nucleotide variants that underlie phenotypic variation can affect chromatin occupancy of transcription factors (TFs). To delineate determinants of in vivo TF binding and chromatin accessibility, we introduce an approach that compares ChIP-seq and DNase-seq data sets from genetically divergent...

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發表在:Nat Commun
Main Authors: Behera, Vivek, Evans, Perry, Face, Carolyne J., Hamagami, Nicole, Sankaranarayanan, Laavanya, Keller, Cheryl A., Giardine, Belinda, Tan, Kai, Hardison, Ross C., Shi, Junwei, Blobel, Gerd A.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5823854/
https://ncbi.nlm.nih.gov/pubmed/29472540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03082-6
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