Methylation-dependent Tissue Factor suppression contributes to the reduced malignancy of IDH1 mutant gliomas

PURPOSE: Gliomas with isocitrate dehydrogenase 1 mutations (IDH1(mut)) are less aggressive than IDH1 wild-type (IDH1(wt)) gliomas and have global genomic hypermethylation. Yet it is unclear how specific hypermethylation events contribute to the IDH1(mut) phenotype. Previously, we showed that the gen...

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Опубликовано в: :Clin Cancer Res
Главные авторы: Unruh, Dusten, Mirkov, Snezana, Wray, Brian, Drumm, Michael, Lamano, Jonathan, Li, Yuping D, Haider, Qazi F., Javier, Rodrigo, McCortney, Kathleen, Saratsis, Amanda, Scholtens, Denise M., Sarkaria, Jann N., James, C. David, Horbinski, Craig
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6537089/
https://ncbi.nlm.nih.gov/pubmed/30266764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1222
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