Modeling the diffusion of D-2-hydroxyglutarate from IDH1 mutant gliomas in the central nervous system

BACKGROUND: Among diffusely infiltrative gliomas in adults, 20%–30% contain a point mutation in isocitrate dehydrogenase 1 (IDH1(mut)), which increases production of D-2-hydroxyglutarate (D2HG). This is so efficient that D2HG often reaches 30 mM within IDH1(mut) gliomas. Yet, while up to 100 µM D2HG...

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Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Linninger, Andreas, Hartung, Grant A, Liu, Benjamin P, Mirkov, Snezana, Tangen, Kevin, Lukas, Rimas V, Unruh, Dusten, James, C David, Sarkaria, Jann N, Horbinski, Craig
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2018
Soggetti:
Basic and Translational Investigations
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071651/
https://ncbi.nlm.nih.gov/pubmed/29660019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy051
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