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TMIC-45. DIFFUSION OF D-2-HYDROXYGLUTARATE FROM IDH1 MUTANT GLIOMAS IN THE BRAIN
Approximately 20-30% of diffusely infiltrative gliomas in adults contain a point mutation in isocitrate dehydrogenase 1 (IDH1mut), which leads to production of D-2-hydroxyglutarate (D2HG). Production of D2HG is so efficient that D2HG concentrations often reach 30 mM within IDH1mut gliomas. Yet, whil...
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| Publicado no: | Neuro Oncol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5692287/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.1033 |
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