TMIC-45. DIFFUSION OF D-2-HYDROXYGLUTARATE FROM IDH1 MUTANT GLIOMAS IN THE BRAIN

Approximately 20-30% of diffusely infiltrative gliomas in adults contain a point mutation in isocitrate dehydrogenase 1 (IDH1mut), which leads to production of D-2-hydroxyglutarate (D2HG). Production of D2HG is so efficient that D2HG concentrations often reach 30 mM within IDH1mut gliomas. Yet, whil...

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Publicat a:Neuro Oncol
Autors principals: Horbinski, Craig, Hartung, Grant, Liu, Benjamin, Mirkov, Snezana, Tangen, Kevin, Unruh, Dusten, Sarkaria, Jann, Linninger, Andreas
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692287/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.1033
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