Epigenetic evolution and lineage histories of chronic lymphocytic leukemia

Genetic and epigenetic intra-tumoral heterogeneity cooperate to shape the evolutionary course of cancer(1). Chronic lymphocytic leukemia (CLL) is a highly informative model for cancer evolution as it undergoes substantial genetic diversification and evolution with therapy(2,3). The CLL epigenome is...

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Udgivet i:Nature
Main Authors: Gaiti, Federico, Chaligne, Ronan, Gu, Hongcang, Brand, Ryan Matthew, Kothen-Hill, Steven, Schulman, Rafael, Grigorev, Kirill, Risso, Davide, Kim, Kyu-Tae, Pastore, Alessandro, Huang, Kevin Y., Alonso, Alicia, Sheridan, Caroline, Omans, Nathaniel D., Biederstedt, Evan, Clement, Kendell, Wang, Lili, Felsenfeld, Joshua A., Bhavsar, Erica B., Aryee, Martin J., Allan, John N., Furman, Richard, Gnirke, Andreas, Wu, Catherine J., Meissner, Alexander, Landau, Dan A.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6533116/
https://ncbi.nlm.nih.gov/pubmed/31092926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1198-z
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