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Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer
In mammals, the canonical somatic DNA methylation landscape is established upon specification of the embryo proper and subsequently disrupted within many cancer types(1-4). However, the underlying mechanisms that direct this genome-scale transformation remain elusive, with no clear model for its sys...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5789792/ https://ncbi.nlm.nih.gov/pubmed/28959968 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature23891 |
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