Interleukin-1β provided by KIT-competent mast cells is required for KRAS-mutant lung adenocarcinoma

Mast cells (MC) have been identified in human lung adenocarcinoma (LADC) tissues, but their functional role has not been investigated in vivo. For this, we applied three mouse models of KRAS-mutant LADC to two different MC-deficient mouse strains (cKit(Wsh) and Cpa3.Cre). Moreover, we derived MC gen...

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發表在:Oncoimmunology
Main Authors: Lilis, Ioannis, Ntaliarda, Giannoula, Papaleonidopoulos, Vassilios, Giotopoulou, Georgia A, Oplopoiou, Maria, Marazioti, Antonia, Spella, Magda, Marwitz, Sebastian, Goldmann, Torsten, Bravou, Vasiliki, Giopanou, Ioanna, Stathopoulos, Georgios T.
格式: Artigo
語言:Inglês
出版: Taylor & Francis 2019
主題:
Original Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527299/
https://ncbi.nlm.nih.gov/pubmed/31143511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2019.1593802
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