Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion

Malignant pleural effusion (MPE) is a frequent metastatic manifestation of human cancers. While we previously identified KRAS mutations as molecular culprits of MPE formation, the underlying mechanism remained unknown. Here, we determine that non-canonical IKKα-RelB pathway activation of KRAS-mutant...

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Publicat a:Nat Commun
Autors principals: Marazioti, Antonia, Lilis, Ioannis, Vreka, Malamati, Apostolopoulou, Hara, Kalogeropoulou, Argyro, Giopanou, Ioanna, Giotopoulou, Georgia A., Krontira, Anthi C., Iliopoulou, Marianthi, Kanellakis, Nikolaos I., Agalioti, Theodora, Giannou, Anastasios D., Jones-Paris, Celestial, Iwakura, Yoichiro, Kardamakis, Dimitrios, Blackwell, Timothy S., Taraviras, Stavros, Spella, Magda, Stathopoulos, Georgios T.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5813197/
https://ncbi.nlm.nih.gov/pubmed/29445180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03051-z
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