IκB kinase α is required for development and progression of KRAS-mutant lung adenocarcinoma

Although oncogenic activation of nuclear factor (NF)-κB has been identified in various tumors, the NF-κB-activating kinases (inhibitor of NF-κB kinases, IKK) responsible for this are elusive. In this study, we determined the role of IKKα and IKKβ in KRAS-mutant lung adenocarcinomas induced by the ca...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Vreka, Malamati, Lilis, Ioannis, Papageorgopoulou, Maria, Giotopoulou, Georgia A., Lianou, Marina, Giopanou, Ioanna, Kanellakis, Nikolaos I., Spella, Magda, Agalioti, Theodora, Armenis, Vasileios, Goldmann, Torsten, Marwitz, Sebastian, Yull, Fiona E., Blackwell, Timothy S., Pasparakis, Manolis, Marazioti, Antonia, Stathopoulos, Georgios T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485619/
https://ncbi.nlm.nih.gov/pubmed/29588349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1944
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