IκB kinase α is required for development and progression of KRAS-mutant lung adenocarcinoma

Although oncogenic activation of nuclear factor (NF)-κB has been identified in various tumors, the NF-κB-activating kinases (inhibitor of NF-κB kinases, IKK) responsible for this are elusive. In this study, we determined the role of IKKα and IKKβ in KRAS-mutant lung adenocarcinomas induced by the ca...

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Publicado no:Cancer Res
Main Authors: Vreka, Malamati, Lilis, Ioannis, Papageorgopoulou, Maria, Giotopoulou, Georgia A., Lianou, Marina, Giopanou, Ioanna, Kanellakis, Nikolaos I., Spella, Magda, Agalioti, Theodora, Armenis, Vasileios, Goldmann, Torsten, Marwitz, Sebastian, Yull, Fiona E., Blackwell, Timothy S., Pasparakis, Manolis, Marazioti, Antonia, Stathopoulos, Georgios T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485619/
https://ncbi.nlm.nih.gov/pubmed/29588349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1944
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