Interleukin-1β provided by KIT-competent mast cells is required for KRAS-mutant lung adenocarcinoma

Mast cells (MC) have been identified in human lung adenocarcinoma (LADC) tissues, but their functional role has not been investigated in vivo. For this, we applied three mouse models of KRAS-mutant LADC to two different MC-deficient mouse strains (cKit(Wsh) and Cpa3.Cre). Moreover, we derived MC gen...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Lilis, Ioannis, Ntaliarda, Giannoula, Papaleonidopoulos, Vassilios, Giotopoulou, Georgia A, Oplopoiou, Maria, Marazioti, Antonia, Spella, Magda, Marwitz, Sebastian, Goldmann, Torsten, Bravou, Vasiliki, Giopanou, Ioanna, Stathopoulos, Georgios T.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527299/
https://ncbi.nlm.nih.gov/pubmed/31143511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2019.1593802
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