Interleukin-1β provided by KIT-competent mast cells is required for KRAS-mutant lung adenocarcinoma

Mast cells (MC) have been identified in human lung adenocarcinoma (LADC) tissues, but their functional role has not been investigated in vivo. For this, we applied three mouse models of KRAS-mutant LADC to two different MC-deficient mouse strains (cKit(Wsh) and Cpa3.Cre). Moreover, we derived MC gen...

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Veröffentlicht in:Oncoimmunology
Hauptverfasser: Lilis, Ioannis, Ntaliarda, Giannoula, Papaleonidopoulos, Vassilios, Giotopoulou, Georgia A, Oplopoiou, Maria, Marazioti, Antonia, Spella, Magda, Marwitz, Sebastian, Goldmann, Torsten, Bravou, Vasiliki, Giopanou, Ioanna, Stathopoulos, Georgios T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2019
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527299/
https://ncbi.nlm.nih.gov/pubmed/31143511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2019.1593802
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